Title :
Contribution of intermediate filaments to cell stiffness
Author :
Wang, Ning ; Stamenovic, D.
Author_Institution :
Physiol. Program, Harvard Sch. of Public Health, Boston, MA, USA
Abstract :
The contribution of intermediate filaments to the steady state mechanical response of adherent cells was assessed by measuring stiffness in wild-type and vimentin deficient fibroblasts using magnetic twisting cytometry. It was found that in the given range of applied stress, the wild-type cells exhibited greater stiffening than the vimentin-deficient cells. This shows that intermediate filaments contribute to strain-induced stiffening response of adherent cells
Keywords :
biological tissues; biomechanics; cellular biophysics; viscoelasticity; adherent cells; cell stiffness; intermediate filaments contribution; magnetic twisting cytometry; steady state mechanical response; strain-induced stiffening response; vimentin deficient fibroblasts; wild-type fibroblasts; Biomedical engineering; Biomedical measurements; Capacitive sensors; Fibroblasts; Magnetic field induced strain; Physiology; Public healthcare; Strain measurement; Stress; Testing;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802102
