Title :
Implications of actin stress fiber buckling in rapidly shortened cells
Author :
Costa, K.D. ; Hucker, W.J. ; Yin, F.C.-P.
Author_Institution :
Biomed. Eng., Washington Univ., St. Louis, MO, USA
Abstract :
To characterize resting tension in the actin cytoskeleton (CSK), human aortic endothelial cells (HAEC) were cultured on a pre-stretched elastic substrate which, when released, shortened the attached cells. The presence of buckled and unbuckled parallel actin stress fibers suggests CSK prestretch may be nonuniformly distributed
Keywords :
biomechanics; buckling; cellular biophysics; mechanoception; proteins; actin cytoskeleton; actin stress fiber buckling; cytoskeleton prestretch; human aortic endothelial cells; macroscopic substrate strain; mechanotransduction; pre-stretched elastic substrate; rapidly shortened cells; resting tension; tortuosity; Biomedical engineering; Capacitive sensors; Cells (biology); Fluorescence; Humans; Injuries; Optical fiber devices; Protein engineering; Stress; Strips;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802103
