Title :
Mechano-transduction in endothelial cells
Author_Institution :
Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA
Abstract :
We studied the mechano-sensors in the endothelial cell membrane that can transduce the mechanical stimulus of shear stress into intracellular biochemical signals. Results indicate that Flk-1, a receptor tyrosine kinase, and integrins and the associated focal adhesion kinases can serve as such mechano-sensors in ECs. The coordinated activation of these and other mechano-sensors can trigger the intracellular signaling pathways to culminate in the modulation of gene expression and other cellular responses
Keywords :
biochemistry; blood vessels; cellular biophysics; mechanoception; coordinated activation; endothelial cell membrane; focal adhesion kinases; integrins; intracellular biochemical signals; intracellular signaling pathways; mechanical stimulus; mechano-sensors; mechano-transduction; modulation of gene expression; receptor tyrosine kinase; shear stress; Adhesives; Amino acids; Biomedical engineering; Biomedical transducers; Biomembranes; Cells (biology); Chemical transducers; Gene expression; Laboratories; Stress;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802144
