Title :
Genetically engineered non-osteoblastic cells expressing a transcriptional activator of osteoblast differentiation
Author :
Byers, B.A. ; Pavlath, G.K. ; García, A.J.
Author_Institution :
Sch. of Mech. Eng., Georgia Inst. of Technol., Atlanta, GA, USA
Abstract :
In order to investigate alternative methods for the development of a tissue-engineered bone graft, this research focuses on forced expression of Osf2, an osteoblast-specific transcriptional activator, in 293 cells. Results indicate that, upon transfection, these non-osteoblastic cells express the Osf2 gene product and, therefore, maybe induced to express the osteoblastic phenotype
Keywords :
bone; cellular biophysics; genetics; genetically engineered nonosteoblastic cells; osteoblast differentiation; osteoblastic phenotype; tissue-engineered bone graft; transcriptional activator; transfection; Bones; Dentistry; Fibroblasts; Fluorescence; Genetic engineering; Immune system; Mechanical engineering; Mineralization; Orthopedic surgery; Proteins;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802150
