Title :
Theoretical and experimental study of intercellular junction-induced sawtooth effect in cardiac cell-pairs
Author :
Sharma, Vinod ; Tung, Leslie
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
We present an analytical expression for the sawtooth amplitude (STA) in an isolated cell-pair with junctional resistance (Rj). Experimentally, STA was estimated in isolated guinea pig cell-pairs by optically recording transmembrane potential responses (Vm) with subcellular spatial resolution. We estimated STA to be ~14 mV for a 10 V/cm field. From theoretical calculations, this corresponds to an Rj of ~22 MΩ
Keywords :
bioelectric potentials; biomembrane transport; cardiology; analytical expression; cardiac cell-pairs; intercellular junction-induced sawtooth effect; isolated guinea pig cell-pairs; junctional resistance; sawtooth amplitude; subcellular spatial resolution; theoretical calculations; transmembrane potential responses; Biomedical engineering; Biomedical optical imaging; Defibrillation; Electric shock; Immune system; Myocardium; Optical recording; Optical sensors; Spatial resolution; Virtual manufacturing;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802179
