Theoretical and experimental study of intercellular junction-induced sawtooth effect in cardiac cell-pairs

Author

Sharma, Vinod ; Tung, Leslie

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA

Volume

1

fYear

1999

fDate

1999

Abstract

We present an analytical expression for the sawtooth amplitude (STA) in an isolated cell-pair with junctional resistance (R_j). Experimentally, STA was estimated in isolated guinea pig cell-pairs by optically recording transmembrane potential responses (V_m) with subcellular spatial resolution. We estimated STA to be ~14 mV for a 10 V/cm field. From theoretical calculations, this corresponds to an R_j of ~22 MΩ

Keywords

bioelectric potentials; biomembrane transport; cardiology; analytical expression; cardiac cell-pairs; intercellular junction-induced sawtooth effect; isolated guinea pig cell-pairs; junctional resistance; sawtooth amplitude; subcellular spatial resolution; theoretical calculations; transmembrane potential responses; Biomedical engineering; Biomedical optical imaging; Defibrillation; Electric shock; Immune system; Myocardium; Optical recording; Optical sensors; Spatial resolution; Virtual manufacturing;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802179

Filename

802179