Title :
Role of calcium-activated chloride currents in heart in pathological conditions: a computer model
Author :
Gomis-Tena, J. ; Saiz, F.J.
Author_Institution :
Dept. de Ingenieria Electron., Valencia Univ., Spain
Abstract :
The aim is to study the influence of transient chloride calcium-dependent outward current (ClCa) on cardiac action potential (AP) at the pathological conditions that induces early after depolarizations (EAD). A detailed mathematical model of this current was introduced into Lindblad-Murphey-Clark-Giles model of cardiac action potential, and the electrical activity in a cell was simulated for various conditions. Our results show that ClCa current must be take into account as important mechanism to avoid EADs generation
Keywords :
bioelectric potentials; biology computing; biomembrane transport; calcium; cardiology; diseases; physiological models; Ca; Ca-activated chloride currents; Cl; Lindblad-Murphey-Clark-Giles model; cardiac action potential; cell; computer model; detailed mathematical model; early after depolarizations; electrical activity; heart; pathological conditions; transient chloride Ca-dependent outward current; Calcium; Electric potential; Equations; Heart; Indium tin oxide; Mathematical model; Permeability; Rabbits; Testing; Voltage;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802185
