Role of calcium-activated chloride currents in heart in pathological conditions: a computer model

Author

Gomis-Tena, J. ; Saiz, F.J.

Author_Institution

Dept. de Ingenieria Electron., Valencia Univ., Spain

Volume

1

fYear

1999

fDate

1999

Abstract

The aim is to study the influence of transient chloride calcium-dependent outward current (Cl_Ca) on cardiac action potential (AP) at the pathological conditions that induces early after depolarizations (EAD). A detailed mathematical model of this current was introduced into Lindblad-Murphey-Clark-Giles model of cardiac action potential, and the electrical activity in a cell was simulated for various conditions. Our results show that Cl_Ca current must be take into account as important mechanism to avoid EADs generation

Keywords

bioelectric potentials; biology computing; biomembrane transport; calcium; cardiology; diseases; physiological models; Ca; Ca-activated chloride currents; Cl; Lindblad-Murphey-Clark-Giles model; cardiac action potential; cell; computer model; detailed mathematical model; early after depolarizations; electrical activity; heart; pathological conditions; transient chloride Ca-dependent outward current; Calcium; Electric potential; Equations; Heart; Indium tin oxide; Mathematical model; Permeability; Rabbits; Testing; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802185

Filename

802185