Detection of neuroendocrine marker in blood samples using an optofluidic chip

Author

Alzghoul, Salah ; Hailat, Mohammad ; Zivanovic, Sandra ; Shah, Girish V. ; Que, Long

Author_Institution

Louisiana Tech Univ., Ruston, LA, USA

fYear

2015

fDate

21-25 June 2015

Firstpage

1703

Lastpage

1706

Abstract

Detection of a newly discovered prostate cancer (PC) biomarker neuroendocrine marker (NEM) using an optofluidic chip, consisting of arrayed optical nanosensors, has been carried out. Different from prostate-specific antigen (PSA), NEM is produced by prostate tumor cells and is released or leaked in blood. Hence, NEM is tumorspecific and more reliable biomarker than PSA. In this effort, for the first time, we have detected 10pg/mL NEM in BSA solution and NEM in blood serum from a patient using the optofluidic chip with high specificity, indicating this type of chip can be potentially used for screening and achieving early detection of PC.

Keywords

blood; cancer; cellular biophysics; nanomedicine; nanosensors; neurophysiology; optical sensors; tumours; arrayed optical nanosensors; blood serum; neuroendocrine marker detection; optofluidic chip; prostate cancer; prostate tumor cells; prostate-specific antigen; Biomedical optical imaging; Blood; Cancer; Nanosensors; Optical device fabrication; Optical sensors; Biomarker detection; biomarkers in blood sample; nanostructured aluminum oxide; optofluidic device;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7181272

Filename

7181272