Low-dimensional model of reentry in loop of cardiac cells

Author

Vinet, Alain

Author_Institution

Inst. de Genie Biomed., Montreal Univ., Que., Canada

Volume

1

fYear

1999

fDate

1999

Abstract

A low dimensional model (LD) using action potential duration (APD) and conduction time (ct) as functions of the diastolic interval (DIA) has been proposed to reproduce the dynamics of propagation in a loop of model cardiac cells (M. Courtemanche et al., 1966). For Beeler-Reuter type (BRT) ionic models, transition from regular to quasiperiodic (QP) propagation occurs at a critical length (L_crit). The authors show that the LD model predicts different forms of transition depending on the form of the APD(DIA) curve that they do not correspond to those observed in BRT ionic models. A modified LD model including the effect of neighbouring cells on the APD is shown to reproduce the dynamics of BRT ionic models

Keywords

bioelectric potentials; cardiology; cellular biophysics; physiological models; Beeler-Reuter type ionic models; action potential duration; cardiac cells loop; cardiac conduction time; cardiac reentry; critical length; electrophysiology; low-dimensional model; neighbouring cells effect; quasiperiodic propagation; regular propagation; Bifurcation; Equations; Fibrillation; Numerical simulation; Predictive models; Quadratic programming; Stability; Switches;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802202

Filename

802202