Title :
Sharp tip-separable microneedle device for trans-dermal drug delivery systems
Author :
Imaeda, K. ; Bessho, K. ; Shikida, M.
Author_Institution :
Dept. of Micro-Nano Syst. Eng., Nagoya Univ., Nagoya, Japan
Abstract :
We developed a sharp tip-separable microneedle device for trans-dermal drug delivery systems (DDSs). Two differently shaped Si-microneedles, eight-sided and rhombic pyramids, were first fabricated by photolithography and anisotropic wet etching. Then, a tip-separable biodegradable microneedles tips was fabricated using a molding process. Thanks to the sharpness of the Si-microneedles, sharp biodegradable tips with the radius of less than 1.0 μm could be fabricated. Finally, the tip-separable microneedle device was successfully used to penetrate a piece of mouse skin.
Keywords :
biodegradable materials; drug delivery systems; elemental semiconductors; etching; needles; photolithography; silicon; Si; anisotropic wet etching; eight-sided rhombic pyramids; photolithography; sharp tip-separable microneedle device; silicon-microneedles; tip-separable biodegradable microneedles; transdermal drug delivery systems; Drug delivery; Drugs; Etching; Fabrication; Needles; Silicon; Skin; Anisotropic wet etching; Drug delivery systems; Eight-sided pyramid; Rhombic pyramid; Tip-separable Micro-needle;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location :
Anchorage, AK
DOI :
10.1109/TRANSDUCERS.2015.7181275
