Seeking a model for study of arrhythmia induction by nonuniform polarization

Author

Baynham, T.C. ; Knisley, S.B.

Author_Institution

Dept. of Biomed. Eng., Alabama Univ., Birmingham, AL, USA

Volume

1

fYear

1999

fDate

1999

Abstract

Nonuniform distribution of changes in transmembrane potential (ΔVm) has been shown to contribute to the induction of arrhythmias in studies using point and intracardiac stimulation. Our objective was to produce a model for the study of arrhythmia induction in isolated, perfused rabbit myocardium using line stimulation during the relative refractory period. The line stimulation electrode was oriented perpendicular to myofibers on the left ventricle of 4 rabbit hearts. We produced adjacent regions of nonuniform polarization in each trial

Keywords

bioelectric potentials; biomembrane transport; cardiology; physiological models; arrhythmia induction; ionic channels; laser scanning recording; left ventricle; line stimulation; model; nonuniform distribution; nonuniform polarization; perfused rabbit myocardium; relative refractory period; transmembrane potential changes; Biomedical engineering; Biomembranes; Electrodes; Fiber lasers; Heart; Myocardium; Optical fiber polarization; Optical propagation; Optical refraction; Rabbits;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802211

Filename

802211