Title :
Seeking a model for study of arrhythmia induction by nonuniform polarization
Author :
Baynham, T.C. ; Knisley, S.B.
Author_Institution :
Dept. of Biomed. Eng., Alabama Univ., Birmingham, AL, USA
Abstract :
Nonuniform distribution of changes in transmembrane potential (ΔVm) has been shown to contribute to the induction of arrhythmias in studies using point and intracardiac stimulation. Our objective was to produce a model for the study of arrhythmia induction in isolated, perfused rabbit myocardium using line stimulation during the relative refractory period. The line stimulation electrode was oriented perpendicular to myofibers on the left ventricle of 4 rabbit hearts. We produced adjacent regions of nonuniform polarization in each trial
Keywords :
bioelectric potentials; biomembrane transport; cardiology; physiological models; arrhythmia induction; ionic channels; laser scanning recording; left ventricle; line stimulation; model; nonuniform distribution; nonuniform polarization; perfused rabbit myocardium; relative refractory period; transmembrane potential changes; Biomedical engineering; Biomembranes; Electrodes; Fiber lasers; Heart; Myocardium; Optical fiber polarization; Optical propagation; Optical refraction; Rabbits;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802211
