Flow affects the biosynthetic activity of aortic valve leaflet fibroblasts

Author

Weston, Matthew W. ; Goldstein, Steven ; Yoganathan, Ajit P.

Author_Institution

Inst. of Bioeng. & Biosci., Georgia Inst. of Technol., Atlanta, GA, USA

Volume

1

fYear

1999

fDate

1999

Abstract

To determine how flow influences the biosynthetic behavior of heart valve leaflet fibroblasts, porcine aortic valve leaflets were exposed to a mean flow rate of either 10 or 20 Lpm for 48 hr under pulsed or steady conditions. Compared to static controls, protein synthesis was reduced by flow, more so at 10 Lpm than at 20 Lpm. No significant differences in synthesis were found between pulsed or steady flow, suggesting that mean flow rate (which creates tensile forces within the leaflet matrix) caused the reduction

Keywords

biological tissues; cardiology; haemodynamics; prosthetics; proteins; aortic valve leaflet fibroblasts; biosynthetic activity; flow influence; mean flow rate; porcine aortic valve leaflets; pulsed conditions; reduced protein synthesis; steady conditions; tensile forces; tissue engineering; Antibiotics; Biomedical engineering; Fibroblasts; Heart rate; Heart valves; In vivo; Proteins; Surface treatment; Tensile stress; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802226

Filename

802226