Title :
Derivation of the diastolic left ventricular wall-thinning to transmitral flow-velocity relation: validation by model-based image processing
Author :
Sessoms, Mark W. ; Milde, Jonathan M. ; Lisauskas, Jennifer B. ; Kovács, Sándor J.
Author_Institution :
Cardiovascular Biophys. Lab., Washington Univ. Sch. of Med., St. Louis, MO, USA
Abstract :
The echocardiographically measured maximal rate of left ventricular (LV) wall-thinning in early diastole has been proposed as a new index of diastolic function. However, its causal relationship to transmitral filling velocity (Doppler E-waves) has not been established. We derived the ventricular wall-thinning to filling relation, using the constant volume of the 4-chamber heart. Left atrio-ventricular geometry was modeled as a constant volume cylinder having a semi-ellipsoid apex and constant external surface. For validation E-wave and color M-Mode images of LV wall thinning were compared to the model predicted filling-velocity to wall-thinning relation. Excellent agreement was observed. We conclude that reasonable assumptions of LV geometry and conservation of volume establish the LV wall-thinning to filling-velocity (Doppler E-wave) relation. Hence, a global, wall-thinning derived diastolic function index is derivable from the transmitral flow velocity (the Doppler E-wave)
Keywords :
echocardiography; haemodynamics; image colour analysis; medical image processing; physiological models; Doppler E-waves; causal relationship; color M-Mode images; constant external surface; constant volume cylinder; diastolic left ventricular wall-thinning; early diastole; echocardiographically measured maximal rate; index of diastolic function; model-based image processing; semi-ellipsoid apex; transmitral filling velocity; transmitral flow-velocity relation; Biomedical imaging; Cardiology; Filling; Geometry; Heart; Image processing; Mathematical model; Myocardium; Predictive models; Valves;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802233