Title :
Regulation of cardiac pressure by ejection velocity
Author :
Landesberg, Amir ; Lichtenstein, Oscar ; Beyar, Rafael ; Sideman, Samuel
Author_Institution :
Dept. of Biomed. Eng., Technion-Israel Inst. of Technol., Haifa, Israel
Abstract :
Left ventricular (LV) mechanical function is determined by the actomyosin crossbridges (Xbs) the motor units of the muscle. The Xb cycles between strong force generating and weak non-force generating conformations. Xb dynamics is regulated by a negative mechanical feedback which controls the rate of Xb turnover from strong to weak conformation. We report the experimental verification of our hypothesis that the transition rate of Xb turnover is determined by the sarcomere shortening velocity
Keywords :
biocontrol; cardiology; feedback; haemodynamics; muscle; actomyosin crossbridges; cardiac pressure regulation; ejection velocity; elastance; isovolume contraction; left ventricular mechanical function; muscle motor units; negative mechanical feedback; sarcomere shortening velocity; strong conformation; turnover transition rate; weak conformation; Anesthesia; Biomedical engineering; Calcium; Control systems; Force control; Heart rate; Muscles; Negative feedback; Pressure control; Transducers;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802276
