Title :
Modeling and identification of cardiovascular hemodynamics in a closed-loop model with ventricular interaction
Author :
Olansen, J.B. ; Clark, J.W. ; Khoury, D. ; Ghorbel, F. ; Bidani, A.
Author_Institution :
Dept. of Mech. Eng., Rice Univ., Houston, TX, USA
Abstract :
A closed-loop model of the cardiopulmonary circulation has been developed for the study of right-left heart interaction under physiologically normal and altered conditions. Model parameters are identified via comparison with canine hemodynamic data using a Levenberg-Marquardt algorithm. The core model provides insight into the affects of ventricular interaction and the pericardium on hemodynamics. Alterations of model parameters can be used to predict the impact of disease and/or clinical interventions on steady-state hemodynamic performance
Keywords :
cardiovascular system; haemodynamics; parameter estimation; physiological models; Levenberg-Marquardt algorithm; canine hemodynamic data; cardiopulmonary circulation; cardiovascular hemodynamics identification; cardiovascular hemodynamics modeling; closed-loop model; disease impact prediction; model parameters identification; physiologically altered conditions; physiologically normal conditions; right-left heart interaction; steady-state hemodynamic performance; Biomedical engineering; Biomedical imaging; Cardiology; Circuits; Educational institutions; Heart; Hemodynamics; Mechanical engineering; Parameter estimation; Transducers;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802311
