Title :
A possible mechanism of abnormal Q waves in hypertrophic cardiomyopathy investigated by model and simulation studies
Author :
Wei, Daming ; Miyamoto, Norio ; Mashima, Saburo
Author_Institution :
Dept. of Comput. Software, Aizu Univ., Fukushima, Japan
Abstract :
To understand genesis of abnormal Q waves in hypertrophic cardiomyopathy (HCM), computer simulation with realistically shaped heart and torso models was conducted based on clinical echocardiogram images and electrocardiograms. Simulated ECGs showing main features of HCM were obtained by assuming random fiber orientations in hypertrophic tissues and by changing other electrophysiologic properties from normal values. This study supports the hypothesis from some pathologic findings that the randomization of hypertrophic tissue orientation may be attributed to the abnormal Q waves in the HCM
Keywords :
bioelectric potentials; electrocardiography; muscle; physiological models; abnormal Q waves; action potential distribution; clinical echocardiogram images; computer simulation; electrocardiograms; electrogenesis; heart models; hypertrophic cardiomyopathy; hypertrophic tissue orientation; random fiber orientations; randomization; realistically shaped models; torso models; Anisotropic magnetoresistance; Cardiology; Computational modeling; Computer simulation; Conductivity; Electrocardiography; Heart; Muscles; Myocardium; Optical fiber testing;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802382
