Title :
Nitric oxide monitoring in hippocampal brain slices
Author :
Rangarajan, R. ; Johnson, L.J. ; Yang, N.C. ; Thakor, N.V.
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA
Abstract :
Nitric Oxide (NO) is known to mediate the excitotoxic injury caused due to overactivation of N-Methyl-D-Aspartate (NMDA) receptors. NO production in response to NMDA receptor activation is studied in three hippocampal subregions: the CA1, CA3 and the Dentate Gyrus (DG). These three regions are differentially sensitive to NMDA toxicity, with the degree of response being the highest in CA1 and the lowest in DG. The results show that the NO production in these regions is different and consistent with their sensitivity to NMDA
Keywords :
biochemistry; brain; monitoring; nitrogen compounds; CA1; CA3; N-methyl-D-aspartate receptors overactivation; NMDA toxicity; NO; dentate gyrus; differentially sensitive regions; excitotoxic injury; hippocampal brain slices; nitric oxide monitoring; Biomedical engineering; Biomedical monitoring; Biosensors; Brain; Computer aided instruction; Electrodes; Hippocampus; Injuries; Neurons; Production;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802442
