Simulation of dendritic structure of pyramidal cells in the cerebral cortex

Author

Togawa, T. ; Otsuka, K.

Author_Institution

Inst. of Biomater. & Bioeng., Tokyo Med. & Dental Univ., Japan

Volume

1

fYear

1999

fDate

1999

Abstract

The authors proposed a model of cortical neural network structure based on the single-cell representation hypothesis and showed that the relation between surface area and thickness of the cortex can be explained consistently (T. Togawa and K. Otsuka, 1980). This study is an attempt of simulating dendritic structure of the neuron in the cortex assuming the total length of a dendrite is proportional to the number of synapses on it. Obtained dendritic structure was compared with the actual morphological structure in animals of different sizes. The apparent similarity of the actual and the simulated dendritic structures suggests the consistency of the proposed model

Keywords

brain models; cellular biophysics; neurophysiology; actual morphological structure; cerebral cortex; dendrite total length; dendritic structure simulation; different sized animals; proposed model consistency; pyramidal cells; synapses number; Animal structures; Biological neural networks; Brain modeling; Cerebral cortex; Humans; Mice; Neurons;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802479

Filename

802479