Title :
Biosynthesis of intervertebral disc matrix in vitro
Author :
Setton, L.A. ; Baer, A.E. ; Wang, Jia ; Kraus, V.B.
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
Cells of the intervertebral disc are shown to express genes for aggrecan and collagen in an in vitro alginate culture system. Despite evidence for significant biosynthesis, the cells appear unable to assemble a mechanically functional matrix in this in vitro system
Keywords :
bone; cellular biophysics; genetics; molecular biophysics; proteins; aggrecan; biosynthesis; cells; collagen; in vitro alginate culture system; intervertebral disc matrix in vitro; mechanically functional matrix; Assembly systems; Biomedical engineering; Biomedical measurements; Cells (biology); Gene expression; In vitro; In vivo; Materials testing; Medical treatment; Sparse matrices;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804494
