Tomographic small-animal imaging using a high-resolution semiconductor camera

The authors have developed a high-resolution, compact semiconductor camera for nuclear medicine applications. The modular unit has been used to obtain tomographic images of phantoms and mice. The system consists of a 64×64 CdZnTe detector array and a parallel-hole tungsten collimator mounted inside a 17 cm×5.3 cm×3.7 cm tungsten-aluminum housing. The detector is a 2.5 cm×2.5 cm×0.15 cm slab of CdZnTe connected to a 64×64 multiplexer readout via indium-bump bonding. The collimator is 7 mm thick, with a 0.38 mm pitch that matches the detector pixel pitch. The authors obtained a series of projections by rotating the object in front of the camera. The axis of rotation was vertical and about 1.5 cm away from the collimator face. Mouse holders were made out of acrylic plastic tubing to facilitate rotation and the administration of gas anesthetic. Acquisition times were varied from 60 sec to 90 sec per image for a total of 60 projections at an equal spacing of 6 degrees between projections. The authors present tomographic images of a line phantom and mouse bone scan and assess the properties of the system. The reconstructed images demonstrate spatial resolution on the order of 1-2 mm