Title :
Decay of sodium currents: second order kinetics in nerve membranes
Author :
Sethumadhavan, H.G. ; Majumder, S.K. ; Venugopal, J.S.
Author_Institution :
Central Food Tech. Res. Inst., Mysore, India
Abstract :
The authors have worked out the kinetics of the sodium inactivation process by the application of voltage-clamp technique using AXOCLAMP-2A. Three measurements were made for the analysis and determination of kinetics of sodium current, namely time course of development of inactivation, time course of recovery from inactivation, and steady-state value of inactivation as a function of potential-revealed second-order kinetics not incorporated in the classical Hodgkin-Huxley equations for the h inactivation parameter.<>
Keywords :
bioelectric phenomena; biomembrane transport; neurophysiology; AXOCLAMP-2A; Na/sup +/ currents; classical Hodgkin-Huxley equations; h inactivation parameter; nerve membranes; neurophysiology; second order kinetics; voltage-clamp technique;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.94969
