Molecular optical probes for imaging tumors

Author

Achilefu, Samuel ; Bloch, Sharon ; Ye, Yunpeng ; Zhang, Zongren ; Dorshow, Richard ; Liang, Kexian

Author_Institution

Washington Univ. Sch. of Med., St. Louis, MO, USA

fYear

2004

fDate

28-30 June 2004

Abstract

Biomedical optical methods provide distinctly new diagnostic capabilities while complementing conventional imaging modalities. To be effective, the molecular probes should produce detectable, quantifiable and discernable signals in response to light absorption or biological activation. Presently, fluorescein, indocyanine green (ICG) and fluorescent photosensitizers are widely used as optical molecular probes for in vivo imaging of tumors, possibly due to their established photophysical properties and safety profile in humans.

Keywords

biomedical optical imaging; cancer; light absorption; molecular biophysics; probes; tumours; ICG; biological activation; biomedical optical method; complementing conventional imaging modality; diagnostic capability; fluorescein; fluorescent photosensitizer; indocyanine green; light absorption; molecular optical probe; photophysical property; tumour in vivo imaging; Absorption; Biomedical imaging; Biomedical optical imaging; Fluorescence; Humans; In vivo; Neoplasms; Optical imaging; Probes; Safety;

fLanguage

English

Publisher

ieee

Conference_Titel

Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004 Digest of the LEOS Summer Topical Meetings

ISSN

1099-4742

Print_ISBN

0-7803-8306-0

Type

conf

DOI

10.1109/LEOSST.2004.1338660

Filename

1338660