Dynamics of HBV model with intermittent antiviral therapy

This paper studies the dynamics of the Hepatitis B virus (HBV) model with intermittent antiviral therapy. We first propose a mathematical model of HBV and then analyze its qualitative and dynamical properties with a new treatment therapy. Combining with the clinical data and theoretical analysis, we show that the intermittent antiviral therapy regimen is one of optimal strategies to treat this kind of complex disease. There are two mainly advantages on this therapy. Firstly, it can delay the drug resistance. Secondly, it can reduce the duration of treatment time comparing with the long term continuous therapy, thereby reducing the adverse side effect. Our results clear provides a new way to treat the HBV disease.