DocumentCode :
3495324
Title :
Neurospheroid array on a flexible substrate for cortical microstimulation
Author :
Okita, Kohei ; Kato-Negishi, M. ; Onoe, H. ; Takeuchi, Shoji
Author_Institution :
Inst. of Ind. Sci., Univ. of Tokyo, Tokyo, Japan
fYear :
2013
fDate :
20-24 Jan. 2013
Firstpage :
221
Lastpage :
224
Abstract :
This paper describes a centimeter-sized flexible multi-electrode array (MEA) integrated with a neuronal spheroid (neurospheroid) array. The MEA has a number of neurospheroids and can be applied to extensively curved surfaces (e.g., brain). We demonstrated that MEA successfully activated neurons within a neurospheroid on the microelectrode array. In addition, the MEA was used to activate 2D culture of cortical cells through the neurospheroids. These results mark an important step toward achieving minimally-invasive cortical microstimulation via neurospheroid-based stimulating systems.
Keywords :
bioelectric phenomena; biomedical electrodes; brain; cellular biophysics; neurophysiology; brain; centimeter-sized flexible multielectrode array; cortical cells; cortical microstimulation; extensively curved surfaces; flexible substrate; minimally-invasive cortical microstimulation; neuronal spheroid array; neurospheroid array; neurospheroid-based stimulating systems; Arrays; Calcium; Electrical stimulation; Fluorescence; Microelectrodes; Neurons;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on
Conference_Location :
Taipei
ISSN :
1084-6999
Print_ISBN :
978-1-4673-5654-1
Type :
conf
DOI :
10.1109/MEMSYS.2013.6474217
Filename :
6474217
Link To Document :
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