Probing of viral diversity by global haplotype prediction

The focus in clinical virology shifts from well-established identification of single nucleotide variants (SNV) to probing of individual viral RNA strains, called haplotypes. The success of antiretroviral treatment of HIV infection heavily depends on the knowledge of an intra-patient´s viral population heterogeneity, because diversity and in particular, low frequency variants affect virulence, immune escape, and drug resistance.