Ventilation and perfusion distributions in lungs obtained by mass spectrometry

Author

Zwart, Aart

Author_Institution

Dept. of Biol. Toxicology, TNO-CIVO Toxicology & Nutrition Inst., Zeist, Netherlands

fYear

1988

fDate

4-7 Nov. 1988

Firstpage

820

Abstract

To study the gas exchange properties of the lung, a method has been developed which allows differentiation between gas exchange limitations due to diffusion limitation or to inhomogeneity of the ventilatory distribution. The technique uses washin and/or washout measurements of inert gases which are poorly soluble in blood. Simultaneous measurement of O/sub 2/ and CO/sub 2/ in the expiratory air flow allows the investigation of ventilation-perfusion inhomogeneities. Functional residual capacity is calculated by integration. The technique requires not special instructions or breathing maneuvers and takes about three minutes. Emphasis is placed on detecting the types of gas limiting processes.<>

Keywords

haemodynamics; lung; pneumodynamics; 3 min; CO/sub 2/; O/sub 2/; diffusion limitation; expiratory air flow; functional residual capacity; gas exchange properties; gas limiting processes; inert gases; lung; mass spectrometry; perfusion distribution; ventilation distribution; washin; washout;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE

Conference_Location

New Orleans, LA, USA

Print_ISBN

0-7803-0785-2

Type

conf

DOI

10.1109/IEMBS.1988.95080

Filename

95080