Title :
Ventilation and perfusion distributions in lungs obtained by mass spectrometry
Author_Institution :
Dept. of Biol. Toxicology, TNO-CIVO Toxicology & Nutrition Inst., Zeist, Netherlands
Abstract :
To study the gas exchange properties of the lung, a method has been developed which allows differentiation between gas exchange limitations due to diffusion limitation or to inhomogeneity of the ventilatory distribution. The technique uses washin and/or washout measurements of inert gases which are poorly soluble in blood. Simultaneous measurement of O/sub 2/ and CO/sub 2/ in the expiratory air flow allows the investigation of ventilation-perfusion inhomogeneities. Functional residual capacity is calculated by integration. The technique requires not special instructions or breathing maneuvers and takes about three minutes. Emphasis is placed on detecting the types of gas limiting processes.<>
Keywords :
haemodynamics; lung; pneumodynamics; 3 min; CO/sub 2/; O/sub 2/; diffusion limitation; expiratory air flow; functional residual capacity; gas exchange properties; gas limiting processes; inert gases; lung; mass spectrometry; perfusion distribution; ventilation distribution; washin; washout;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.95080
