DocumentCode
3499118
Title
Magnetophoresis for mononuclear cell separation and diagnostic evaluation of the phagocytic capacity of monocyte
Author
Minamitani, Haruyuki ; Shimomura, Takuji ; Aiba, Masayuki ; Okada, Eiji
Author_Institution
Dept. of Electr. Eng., Keio Univ., Yokohama, Japan
fYear
1988
fDate
4-7 Nov. 1988
Firstpage
1328
Abstract
The authors discuss magnetophoresis, which specifically separates monocytes phagocytizing iron dextran microspheres from mononuclear cell suspensions under a DC magnetic field. Diagnostic evaluation of the phagocytic capacity was carried out for patients with liver diseases on the basis of the separation efficiency of the monocytes. Results of the magnetic separation showed that the phagocytic capacities of hepatoma and liver cirrhosis patients were significantly lower than those of healthy volunteers. Magnetophoresis was found to be essential in investigating the phagocytosis.<>
Keywords
biomagnetism; cellular biophysics; liver; patient diagnosis; Fe dextran microspheres; hepatoma; liver cirrhosis; liver disease patients; magnetophoresis; mononuclear cell separation; phagocytic capacity evaluation;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location
New Orleans, LA, USA
Print_ISBN
0-7803-0785-2
Type
conf
DOI
10.1109/IEMBS.1988.95127
Filename
95127
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