Dissolvable mobile microplates for handling adherent cells

Author

Yoshida, Sigeru ; Takeuchi, Shoji

Author_Institution

Inst. of Ind. Sci., Univ. of Tokyo, Tokyo, Japan

fYear

2013

fDate

20-24 Jan. 2013

Firstpage

959

Lastpage

962

Abstract

This paper describes a preliminary report of microfabricated dissolvable mobile microplates for handling adherent cells. We fabricated micron-sized (10~100 μm) alginate hydrogel plates by soft lithography, attached adherent cells, and handled them. In contrast to previous microplates [1-3], the alginate microplates could be dissolved without damaging cells. We demonstrated dissolution of microplates after cell handling, which resulted in changing positions of adherent cells without direct contact. We believe our method will be applicable to on-demand handling, location, and assembly of adherent cells for basic biological studies and tissue engineering.

Keywords

adhesion; bioMEMS; cellular biophysics; dissolving; hydrogels; microfabrication; microfluidics; soft lithography; adherent cell assembly; adherent cell attachment; adherent cell handling; biological studies; dissolution; microfabricated dissolvable mobile microplates; micron-sized alginate hydrogel plates; on-demand handling; size 10 mum to 100 mum; soft lithography; tissue engineering; Arrays; Cells (biology); Glass; Microscopy; Mobile communication; Soft lithography;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on

Conference_Location

Taipei

ISSN

1084-6999

Print_ISBN

978-1-4673-5654-1

Type

conf

DOI

10.1109/MEMSYS.2013.6474405

Filename

6474405