Modeling normal/epileptic brain dynamics with potential application in titration therapy

The KIV (K-4) model is based on biological attributes found in the limbic system of a salamander. Higher forms of organisms including humans have a limbic system which incorporates the sensory cortex, hippocampus and entorhinal cortex/amygdala of the brain. The KIV model has been used successfully for classification and prediction tasks. We propose the use of the KIV model as a metaphor of the limbic system of the human brain. The brain states of normal/pathological (seizure)/restoration are modeled to further understand the pathological states of the brain and propose a titration therapy through this model.