Neuronal electrical activity, energy consumption and mitochondrial ATP restoration dynamics: A physiological based model for FMRI

Author

Gafaniz, Rita ; Sanches, J. Miguel

Author_Institution

Inst. for Syst. & Robotic, Inst. Super. Tecnico, Lisbon, Portugal

fYear

2011

fDate

March 30 2011-April 2 2011

Firstpage

341

Lastpage

344

Abstract

fMRI is a widely used method to detect the activated brain regions due to a stimulus application. Commonly, it employs the BOLD contrast, which is based on the correlation between physiological function, energy metabolism and haemodynamics. However, the BOLD signal is weak and noisy, so that, an accurate mathematical model to describe the Haemodynamic Response Function (HRF) to activation is needed.

Keywords

bioelectric phenomena; biomedical MRI; cellular biophysics; molecular biophysics; neurophysiology; BOLD contrast; activated brain regions; energy consumption; energy metabolism; fMRI; haemodynamic response function; haemodynamics; mathematical model; mitochondrial ATP restoration dynamics; neuronal electrical activity; physiological function; physiological-based model; stimulus application; Biochemistry; Blood flow; Equations; Mathematical model; Neurons; Poles and zeros; Regulators; BOLD; Neuro-Metabolic Model; fMRI;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on

Conference_Location

Chicago, IL

ISSN

1945-7928

Print_ISBN

978-1-4244-4127-3

Electronic_ISBN

1945-7928

Type

conf

DOI

10.1109/ISBI.2011.5872419

Filename

5872419