Fast virtual destaining of immunocytological specimens

Author

Bell, A.A. ; Friedrich, D. ; Chaisaowong, K. ; Braunschweig, T. ; Knüchel-Clarke, R. ; Aach, T.

Author_Institution

Inst. of Imaging & Comput. Vision, RWTH Aachen Univ., Aachen, Germany

fYear

2011

fDate

March 30 2011-April 2 2011

Firstpage

914

Lastpage

917

Abstract

Microscopy-based diagnosis of certain diseases or infections, e.g. with human papilloma viruses (HPV) for the identification of high risk patients for cervical cancer, relies more and more often on immunocytochemical marker stains. These markers stain cells that exhibit a particular protein. In addition to one or more marker stains, pathologists need to simultaneously assess the morphology of the cell. Therefore the specimens are commonly also stained with a counter stain.

Keywords

biochemistry; biomedical optical imaging; cancer; cellular biophysics; image colour analysis; medical image processing; molecular biophysics; optical microscopy; proteins; cell morphology; cervical cancer; color space conversion; diseases; fast virtual destaining; human papilloma viruses; immunocytochemical marker stains; immunocytological specimens; infections; microscopy-based diagnosis; protein; specific color transformation; Image color analysis; Microscopy; Optical attenuators; Optical imaging; Optical sensors; Radiation detectors; Table lookup; cancer diagnosis; color separation; cytology; immunocytochemical marker; virtual destaining;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on

Conference_Location

Chicago, IL

ISSN

1945-7928

Print_ISBN

978-1-4244-4127-3

Electronic_ISBN

1945-7928

Type

conf

DOI

10.1109/ISBI.2011.5872552

Filename

5872552