DocumentCode
351116
Title
Analysis of repeated measurements in clinical studies: departures from study design
Author
Wagenpfeil, S. ; Hennig, M. ; Kates, R. ; Neiss, A.
Author_Institution
Inst. fur Med. Stat. und Epidemiologie, Tech. Univ. Munchen, Germany
fYear
1999
fDate
36495
Firstpage
313
Lastpage
315
Abstract
This paper shows how three commonly occurring types of deviations from clinical study protocols (missing values, deviations of planned measurement intervals, and outliers) may be taken into account within a statistical framework. The techniques are described for a linear explanatory model, but they could be of considerable use in a more general nonlinear context as well
Keywords
biomedical measurement; design of experiments; statistical analysis; time series; clinical study protocol deviations; design departures; linear explanatory model; medical statistics; missing data; missing values; nonlinear models; outliers; planned measurement intervals; repeated measurements; statistical framework; time series; Analytical models; Context modeling; Diseases; Human factors; Intelligent systems; Protocols; Scattering; Statistics; Thickness measurement; Time measurement;
fLanguage
English
Publisher
ieee
Conference_Titel
Knowledge-Based Intelligent Information Engineering Systems, 1999. Third International Conference
Conference_Location
Adelaide, SA
Print_ISBN
0-7803-5578-4
Type
conf
DOI
10.1109/KES.1999.820186
Filename
820186
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