Title :
First in vivo studies on rats with the YAPPET scanner
Author :
Guerra, A. Del ; Damiani, C. ; Domenico, G. Di ; Giganti, M. ; Motta, A. ; Piffanelli, A. ; Uccelli, L. ; Zavattini, G. ; Bettinardi, V. ; Gilardi, M.C. ; Moresco, R.M. ; Fazio, F.
Author_Institution :
Dept. of Phys., Pisa Univ., Italy
Abstract :
At Ferrara University the authors have built a dedicated 3-D PET scanner (YAPPET) with a very high spatial resolution and sensitivity as necessary for radiopharmaceutical studies on rats and mice. In collaboration with the Institute H.S. Raffaele in Milano the authors have performed both distribution and dynamical uptake studies of various radioactive tracers in rats. They have performed tomographic studies after injecting live rats with FDG and FESP labeled with 18F, with FE-CIT and Flumazenil labeled with 11C, and with 18 F. The 18F-FDG, 18F-FESP and 11C-FE-CIT images show the different distribution of the various tracers in the rat brain. The 18F was injected for imaging the rat skeleton. In addition, the authors studied the uptake and washout curve of 11C Flumazenil in the rat brain from tomographic images
Keywords :
biomedical equipment; brain; image resolution; orthopaedics; positron emission tomography; 11C; 11C-FE-CIT; 18F; 18F-FDG; 18F-FESP; C; F; FE-CIT; FESP; Ferrara University; Flumazenil; Institute H.S. Raffaele; YAPPET scanner; dedicated 3-D PET scanner; dynamical uptake studies; in vivo studies; mice; radiopharmaceutical studies; rat skeleton; rats; spatial resolution; tomographic studies; Animals; Detectors; Image reconstruction; Imaging phantoms; In vivo; Mice; Physics; Positron emission tomography; Rats; Spatial resolution;
Conference_Titel :
Nuclear Science Symposium, 1999. Conference Record. 1999 IEEE
Conference_Location :
Seattle, WA
Print_ISBN :
0-7803-5696-9
DOI :
10.1109/NSSMIC.1999.842837
