Title :
Evaluating Protein Sequence Signatures Inferred from Protein-Protein Interaction Data by Gene Ontology Annotations
Author :
Maruyama, Osamu ; Hirakawa, Hideki ; Iwayanagi, Takao ; Ishida, Yoshiko ; Takeda, Shizu ; Otomo, Jun ; Kuhara, Satoru
Author_Institution :
Fac. of Math., Kyushu Univ., Fukuoka
Abstract :
We propose a systematic method to find sequence signatures of proteins which share a common interacting partner, using a protein similarity measure based on gene ontology (GO) annotations. In a computational experiment on our original human data set of protein-protein interactions determined by Y2H assays, we have succeeded in discovering convincing candidates for interacting sites and other functional regions.
Keywords :
bioinformatics; genomics; molecular biophysics; ontologies (artificial intelligence); proteins; Y2H assays; gene ontology annotation; protein sequence; protein similarity measure; protein-protein interaction; Bioinformatics; Ontologies; Protein sequence; Protein-protein interaction; gene ontology; interaction site; sequence signature;
Conference_Titel :
Bioinformatics and Biomedicine, 2008. BIBM '08. IEEE International Conference on
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-0-7695-3452-7
DOI :
10.1109/BIBM.2008.29
