A simple PK/PD model identification procedure for controller design in anesthesia

In this paper a new estimation procedure for the parameters of the PK/PD model for the simultaneous administration of propofol and remifentanil introduced in [1] is presented. This model has the advantage of being parsimoniously parameterized, which allows a simple parameter estimation procedure, based on the patient´s step response. It is shown that the parameter estimates obtained in this way provide good results when used to tune the positive control law introduced in [2].