Title :
A CMOS-Compatible Biological Transducer for Creatinine Detection: MIP-Gate ISFET
Author :
Lin, Chen-Fu ; Tsai, Hann-Huei ; Juang, Ying-Zong ; Su, Yan-Kuin ; Li, Wang-Long ; Wang, Ruey-Lue ; Lin, Hung-Yin ; Guo, Jia-Yu ; Tsai, Tian-Jun ; Liu, Bin-Da
Author_Institution :
Nat. Chip Implementation Center, Nat. Appl. Res. Labs., Hsinchu
Abstract :
In this paper, it demonstrates a CMOS-compatible transducer for creatinine detection. Different with traditional application of ISFET (Ion Selective Field Effect Transistor), it is not for the hydrogen ion detection. To combine the CMOS MEMS platform with MIP (Molecular Imprinting Polymer) micro coating technologies, the developed MlP-gate ISFET could be used for the detecting of creatinine. The experiment results showed that the difference of response current was about 13? A when the concentration was varied from 0.199 mg/mL to 0.787 mg/mL. Beside, this paper successfully demonstrates the possibility of the liquid isolation and localized MIP coating technology.
Keywords :
CMOS integrated circuits; biomedical transducers; biosensors; coating techniques; ion sensitive field effect transistors; micromechanical devices; polymers; CMOS-compatible biological transducer; MEMS platform; MlP-gate ISFET; creatinine detection; ion selective field effect transistor; liquid isolation; microcoating technologies; molecular imprinting polymer; Biomembranes; Biosensors; CMOS process; CMOS technology; Chemical transducers; Coatings; Hydrogen; MOSFET circuits; Micromechanical devices; Polymers;
Conference_Titel :
Testing and Diagnosis, 2009. ICTD 2009. IEEE Circuits and Systems International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-2587-7
DOI :
10.1109/CAS-ICTD.2009.4960739
