Handling arbitrary unknown lineshape in in vivo MRS without searching in function space

In vivo Magnetic Resonance Spectroscopy (MRS) is the only technique that can non-invasely detect metabolites at arbitrary locations inside humans and animals. Because metabolites serve as markers of disease, estimation of their in vivo concentrations (quantitation) is important. Metabolite quantitation suffers when the model function of the in vivo MRS signal is only partially known. The present work concentrates on handling arbitrary unknown MRS lineshape, introducing a new approach to the problem addressed at IST 2008. Its main characteristic is that searching in function space, normally needed for modelling lineshapes of a priori unknown form, is circumvented.