DocumentCode
3535149
Title
Impact of PSF modelling on the convergence rate and edge behaviour of EM images in PET
Author
Thielemans, K. ; Asma, E. ; Ahn, S. ; Manjeshwar, RM ; Deller, T. ; Ross, SG ; Stearns, CW ; Ganin, A.
Author_Institution
Hammersmith Hosp., Hammersmith Imanet Ltd., London, UK
fYear
2010
fDate
Oct. 30 2010-Nov. 6 2010
Firstpage
3267
Lastpage
3272
Abstract
EM reconstructions with point-spread-function (PSF) modelling is performed to increase the spatial resolution in PET images. These images exhibit slower initial convergence compared to reconstructions without PSF modelling. Furthermore, they exhibit more pronounced ringing around the edges of sharp features. We investigate the effect of different objects and PSF modelling on the convergence rate and edge behaviour of the EM algorithm in two stages: (i) at the initial iterations where the updates are large and (ii) at the later iterations where the updates are small. For the initial iterations, we compare the sharpness of the EM updates with and without PSF modelling. We show via simulations that the PSF modelling during the backprojection step causes smoother updates and consequently smoother images in the early stages of the EM algorithm. For the later iterations, we approximate the image as the ML image plus a perturbation term and develop an approximate update equation for the perturbation, which depends on the Hessian (H) of the log-likelihood. Based on this equation and the spectral analysis of H, we demonstrate how edges with ringing are preserved in the later stages of the algorithm and eliminated only for the case of noiseless data reconstruction with an unrealistically high number of iterations. In addition, we provide an intuitive explanation for the creation of the edge artefacts in terms of the PSF modelling during the backprojection step.
Keywords
Hessian matrices; data analysis; edge detection; image reconstruction; iterative methods; medical image processing; optical transfer function; positron emission tomography; spectral analysis; EM reconstruction algorithm; Hessian matrix; PET images; backprojection method; edge artefacts; iterative method; log-likelihood; noiseless data reconstruction; point-spread-function modelling; spectral analysis; Convergence; Eigenvalues and eigenfunctions; Image edge detection; Image reconstruction; Image resolution; Kernel; Mathematical model;
fLanguage
English
Publisher
ieee
Conference_Titel
Nuclear Science Symposium Conference Record (NSS/MIC), 2010 IEEE
Conference_Location
Knoxville, TN
ISSN
1095-7863
Print_ISBN
978-1-4244-9106-3
Type
conf
DOI
10.1109/NSSMIC.2010.5874409
Filename
5874409
Link To Document