• DocumentCode
    3535149
  • Title

    Impact of PSF modelling on the convergence rate and edge behaviour of EM images in PET

  • Author

    Thielemans, K. ; Asma, E. ; Ahn, S. ; Manjeshwar, RM ; Deller, T. ; Ross, SG ; Stearns, CW ; Ganin, A.

  • Author_Institution
    Hammersmith Hosp., Hammersmith Imanet Ltd., London, UK
  • fYear
    2010
  • fDate
    Oct. 30 2010-Nov. 6 2010
  • Firstpage
    3267
  • Lastpage
    3272
  • Abstract
    EM reconstructions with point-spread-function (PSF) modelling is performed to increase the spatial resolution in PET images. These images exhibit slower initial convergence compared to reconstructions without PSF modelling. Furthermore, they exhibit more pronounced ringing around the edges of sharp features. We investigate the effect of different objects and PSF modelling on the convergence rate and edge behaviour of the EM algorithm in two stages: (i) at the initial iterations where the updates are large and (ii) at the later iterations where the updates are small. For the initial iterations, we compare the sharpness of the EM updates with and without PSF modelling. We show via simulations that the PSF modelling during the backprojection step causes smoother updates and consequently smoother images in the early stages of the EM algorithm. For the later iterations, we approximate the image as the ML image plus a perturbation term and develop an approximate update equation for the perturbation, which depends on the Hessian (H) of the log-likelihood. Based on this equation and the spectral analysis of H, we demonstrate how edges with ringing are preserved in the later stages of the algorithm and eliminated only for the case of noiseless data reconstruction with an unrealistically high number of iterations. In addition, we provide an intuitive explanation for the creation of the edge artefacts in terms of the PSF modelling during the backprojection step.
  • Keywords
    Hessian matrices; data analysis; edge detection; image reconstruction; iterative methods; medical image processing; optical transfer function; positron emission tomography; spectral analysis; EM reconstruction algorithm; Hessian matrix; PET images; backprojection method; edge artefacts; iterative method; log-likelihood; noiseless data reconstruction; point-spread-function modelling; spectral analysis; Convergence; Eigenvalues and eigenfunctions; Image edge detection; Image reconstruction; Image resolution; Kernel; Mathematical model;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Nuclear Science Symposium Conference Record (NSS/MIC), 2010 IEEE
  • Conference_Location
    Knoxville, TN
  • ISSN
    1095-7863
  • Print_ISBN
    978-1-4244-9106-3
  • Type

    conf

  • DOI
    10.1109/NSSMIC.2010.5874409
  • Filename
    5874409