DocumentCode
3542629
Title
Multiple reaction monitoring: Modeling and systematic analysis
Author
Atashpaz-Gargari, Esmaeil ; Braga-Neto, Ulisses M. ; Dougherty, Edward R.
Author_Institution
Dept. of Electr. & Comput. Eng., Texas A&M Univ., College Station, TX, USA
fYear
2011
fDate
4-6 Dec. 2011
Firstpage
105
Lastpage
107
Abstract
Mass Spectrometry in Multiple Reaction Monitoring (MRM) mode is becoming increasingly used in the validation of protein biomarkers. In a systematic approach toward studying MRM, in this paper, the biomarker validation pipeline using this method is modeled. Numerical experiments based on this model are used to study the effect of different parameters on the final performance of biomarker validation.
Keywords
biochemistry; mass spectroscopic chemical analysis; molecular biophysics; physiological models; proteins; biomarker validation pipeline; mass spectrometry; multiple reaction monitoring; protein biomarkers; systematic analysis; Biological system modeling; Biomarkers; Monitoring; Noise; Peptides; Protein engineering; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on
Conference_Location
San Antonio, TX
ISSN
2150-3001
Print_ISBN
978-1-4673-0491-7
Electronic_ISBN
2150-3001
Type
conf
DOI
10.1109/GENSiPS.2011.6169455
Filename
6169455
Link To Document