DocumentCode :
3547093
Title :
Dynamic bidirectional conductance modulation during DNA translocation in a nanofluidic channel
Author :
Sen, Yi-Heng ; Karnik, Rohit
Author_Institution :
Massachusetts Inst. of Technol., Cambridge, MA, USA
fYear :
2012
fDate :
Jan. 29 2012-Feb. 2 2012
Firstpage :
812
Lastpage :
814
Abstract :
We report bidirectional conductance modulation in synthetic nanochannels introduced by the translocation of λ-DNA molecules. The translocation signal comprised conductance decrease followed by conductance increase in the same translocation event. The results are consistent with concentration enhancement and depletion effects caused by introduction of asymmetric charge into the nanochannel due to the translocating molecule.
Keywords :
DNA; biological techniques; electrical conductivity; molecular biophysics; nanobiotechnology; nanofluidics; λ-DNA molecules; DNA translocation; dynamic bidirectional conductance modulation; nanofluidic channel; synthetic nanochannel; translocation signal; Current measurement; DNA; Ions; Laboratories; Modulation; Nanoscale devices; Numerical simulation;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on
Conference_Location :
Paris
ISSN :
1084-6999
Print_ISBN :
978-1-4673-0324-8
Type :
conf
DOI :
10.1109/MEMSYS.2012.6170310
Filename :
6170310
Link To Document :
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