• DocumentCode
    3547093
  • Title

    Dynamic bidirectional conductance modulation during DNA translocation in a nanofluidic channel

  • Author

    Sen, Yi-Heng ; Karnik, Rohit

  • Author_Institution
    Massachusetts Inst. of Technol., Cambridge, MA, USA
  • fYear
    2012
  • fDate
    Jan. 29 2012-Feb. 2 2012
  • Firstpage
    812
  • Lastpage
    814
  • Abstract
    We report bidirectional conductance modulation in synthetic nanochannels introduced by the translocation of λ-DNA molecules. The translocation signal comprised conductance decrease followed by conductance increase in the same translocation event. The results are consistent with concentration enhancement and depletion effects caused by introduction of asymmetric charge into the nanochannel due to the translocating molecule.
  • Keywords
    DNA; biological techniques; electrical conductivity; molecular biophysics; nanobiotechnology; nanofluidics; λ-DNA molecules; DNA translocation; dynamic bidirectional conductance modulation; nanofluidic channel; synthetic nanochannel; translocation signal; Current measurement; DNA; Ions; Laboratories; Modulation; Nanoscale devices; Numerical simulation;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on
  • Conference_Location
    Paris
  • ISSN
    1084-6999
  • Print_ISBN
    978-1-4673-0324-8
  • Type

    conf

  • DOI
    10.1109/MEMSYS.2012.6170310
  • Filename
    6170310
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3547093