Title :
Dynamic bidirectional conductance modulation during DNA translocation in a nanofluidic channel
Author :
Sen, Yi-Heng ; Karnik, Rohit
Author_Institution :
Massachusetts Inst. of Technol., Cambridge, MA, USA
fDate :
Jan. 29 2012-Feb. 2 2012
Abstract :
We report bidirectional conductance modulation in synthetic nanochannels introduced by the translocation of λ-DNA molecules. The translocation signal comprised conductance decrease followed by conductance increase in the same translocation event. The results are consistent with concentration enhancement and depletion effects caused by introduction of asymmetric charge into the nanochannel due to the translocating molecule.
Keywords :
DNA; biological techniques; electrical conductivity; molecular biophysics; nanobiotechnology; nanofluidics; λ-DNA molecules; DNA translocation; dynamic bidirectional conductance modulation; nanofluidic channel; synthetic nanochannel; translocation signal; Current measurement; DNA; Ions; Laboratories; Modulation; Nanoscale devices; Numerical simulation;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on
Conference_Location :
Paris
Print_ISBN :
978-1-4673-0324-8
DOI :
10.1109/MEMSYS.2012.6170310
