Study of morphological changes of neuroblastoma cells induced by activation of NMDA receptor

Neurodegeneration has been recognized as the main cause for neuronal diseases. Much effort has been paid to investigate the process of neurodegeneration from the viewpoint of molecular biology. However, the mechanisms of some processes are still unclear. Here we use a new means to study neurodegeneration using atomic force microscopy (AFM) from the aspect of cellular integrity. The morphological information of neuroblastoma cells was obtained by AFM and it showed a great difference in the process of neurodegeneration induced by activation of NMDA receptors.