• DocumentCode
    3549913
  • Title

    Active CMOS biochip for time-resolved fluorescence detection

  • Author

    Patounakis, George ; Shepard, K.L. ; Levicky, R.

  • Author_Institution
    Dept. of Electr. Eng., Columbia Univ., New York, NY, USA
  • fYear
    2005
  • fDate
    16-18 June 2005
  • Firstpage
    68
  • Lastpage
    71
  • Abstract
    This paper describes the design of an active CMOS biosensor array for fluorescence-based assays which enables time-gated, time-resolved fluorescence spectroscopy. The array is sensitive to photon densities as low as 1.15 × 108/cm2, has a dynamic range of over 74 dB, and has sub-nanosecond timing resolution. High sensitivity is achieved through subsampling and averaging.
  • Keywords
    CMOS integrated circuits; biosensors; fluorescence; medical signal detection; time resolved spectroscopy; active CMOS biochip; averaging; dynamic range; photon density; spectroscopy; subsampling; time resolved fluorescence detection; timing resolution; Biomedical optical imaging; Biosensors; Fluorescence; Laser excitation; Optical filters; Optical losses; Optical sensors; Photodiodes; Probes; Spectroscopy;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    VLSI Circuits, 2005. Digest of Technical Papers. 2005 Symposium on
  • Print_ISBN
    4-900784-01-X
  • Type

    conf

  • DOI
    10.1109/VLSIC.2005.1469336
  • Filename
    1469336
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3549913