DocumentCode
3550677
Title
A quantitative model of the human thyroid: development and observations
Author
Degon, M. ; Chait, Y ; Hollot, C.V. ; Chipkin, S. ; Zoeller, T.
fYear
2005
fDate
8-10 June 2005
Firstpage
961
Abstract
A qualitative dynamical model of a human thyroid is derived using known intrathyroidal processes and pathways. It includes iodide transports from plasma into the thyroid and from the cell to the colloid, thyroid-stimulating hormone signaling pathways, organisation, endocytosis, proteolysis, and hormone synthesis. Using mainly Michaelis-Menton kinetics, a quantitative model is derived at nominal values of internal concentrations. Simulations at different conditions demonstrate the ability of this model to predict several types of known thyroid behavior such as the Wolff-Chaikoff effect.
Keywords
cellular biophysics; colloids; physiological models; Michaelis-Menton kinetics; endocytosis; hormone synthesis; human thyroid behavior; intrathyroidal processes; iodide transports; plasma; proteolysis; qualitative dynamical model; quantitative model; thyroid-stimulating hormone signaling pathways; Biochemistry; Biomembranes; Electric breakdown; Extracellular; Humans; Laboratories; Plasma transport processes; Proteins; Raw materials; Signal synthesis;
fLanguage
English
Publisher
ieee
Conference_Titel
American Control Conference, 2005. Proceedings of the 2005
ISSN
0743-1619
Print_ISBN
0-7803-9098-9
Electronic_ISBN
0743-1619
Type
conf
DOI
10.1109/ACC.2005.1470084
Filename
1470084
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