On-line application oriented scheduling for fed-batch antibiotic fermentation

The great variance of cultivation periods of different antibiotic fermentation batches operated empirically results in potential loss in the economic profit and many disturbances on upstream and downstream units. With the prediction of profit function, on-line application oriented scheduling strategy for antibiotic fermentation is proposed. The scheduling intervals and the scheduling functions are introduced for fixed and flexible termination intervals. The scheduling strategies may give the optimal termination sequence of batches. The termination criterion of the optimal operation period is also presented. The scheduling strategies optimize the cultivation periods. Pseudo on-line testing using the proposed scheduling strategies is applied with the data from a Chinese pharmaceutical factory.