DocumentCode :
35530
Title :
Understanding the aristolochic acid toxicities in rat kidneys with regulatory networks
Author :
Yin-Ying Wang ; Zhiguang Li ; Tao Chen ; Xing-Ming Zhao
Author_Institution :
Inst. of Syst. Biol., Shanghai Univ., Shanghai, China
Volume :
9
Issue :
4
fYear :
2015
fDate :
8 2015
Firstpage :
141
Lastpage :
146
Abstract :
The natural products containing aristolochic acid (AA) have been widely used for acne, gastritis and so on. Recently, it is becoming accepted that AA may be responsible for acute and chronic renal failures as the side effects of Chinese herbs. However, it is unclear what happens in the cells after the AA treatment. In this study, the authors built a gene regulatory network as well as a microRNA-gene regulatory network to investigate the molecular dynamics induced by AA from a systematic perspective. With the regulatory networks, they detected some important pathways and biological processes that were affected by AA treatment, which can help explain the nephrotoxicity and carcinogenicity of AA. They found some important regulators and genes responding to AA treatment, and these genes have been reported to be related to the kidney functions, indicating their important roles in the toxicity of AA.
Keywords :
RNA; bioinformatics; cancer; genetics; kidney; molecular biophysics; toxicology; Chinese herbs; acne; acute renal failures; aristolochic acid toxicities; carcinogenicity; chronic renal failures; gastritis; gene regulatory network; microRNA-gene regulatory network; molecular dynamics; nephrotoxicity; rat kidneys; regulatory networks;
fLanguage :
English
Journal_Title :
Systems Biology, IET
Publisher :
iet
ISSN :
1751-8849
Type :
jour
DOI :
10.1049/iet-syb.2014.0057
Filename :
7181752
Link To Document :
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