Apoptosis Experiments of Cultured Tumor Cells Treated With 200- $\\mu\\hbox {m}$ -Sized Flexible Microplasma Jet

Author

Kim, Jae Young ; Ballato, John ; Foy, Paul ; Hawkins, Thomas ; Wei, Yanzhang ; Li, Jinhua ; Kim, Sung-O

Author_Institution

Holcombe Dept. of Electr. & Comput. Eng., Clemson Univ., Clemson, SC, USA

Volume

39

Issue

11

fYear

2011

Firstpage

2974

Lastpage

2975

Abstract

A flexible atmospheric pressure microplasma jet device utilizing a 200-μm hollow-core optical fiber was developed in order to trigger the apoptosis of cultured tumor cells and determine the feasibility of plasma endoscopy. As determined by in situ apoptosis assay, the TUNEL assay, this flexible microplasma jet induced cultured murine tumor cells to undergo apoptosis. In addition, the apoptosis was induced to a greater extent in B16F0 tumor cells than in CL.7 cells for the same plasma dose.

Keywords

cancer; endoscopes; optical fibres; plasma applications; plasma devices; plasma jets; tumours; B16F0 tumor cells; TUNEL assay; apoptosis assay; cultured murine tumor cells; cultured tumor cell apoptosis; flexible microplasma jet device; hollow-core optical fiber; plasma dose; plasma endoscopy; pressure 1 atm; size 200 mum; Biomedical optical imaging; Cancer; Electron tubes; Malignant tumors; Medical treatment; Plasmas; Apoptosis experiment; flexible atmospheric pressure microplasma jet; plasma cancer therapy;

fLanguage

English

Journal_Title

Plasma Science, IEEE Transactions on

Publisher

ieee

Conference_Location

5/2/2011 12:00:00 AM

ISSN

0093-3813

Type

jour

DOI

10.1109/TPS.2011.2134111

Filename

5762368

Apoptosis Experiments of Cultured Tumor Cells Treated With 200- -Sized Flexible Microplasma Jet

Kim, Jae Young ; Ballato, John ; Foy, Paul ; Hawkins, Thomas ; Wei, Yanzhang ; Li, Jinhua ; Kim, Sung-O

jour

Apoptosis Experiments of Cultured Tumor Cells Treated With 200- $\\mu\\hbox {m}$ -Sized Flexible Microplasma Jet