Title :
Scouting enzyme behavior
Author :
Matsumaru, Naoki ; Colombano, Silvano ; Zauner, Klaus-Peter
Author_Institution :
Dept. of Comput. Sci., Wayne State Univ., Detroit, MI, USA
Abstract :
Experimental exploration of enzymatic response in a multidimensional context faces the challenge of an explosive number of possible milieu conditions. We address this problem with an evolutionary search strategy that scouts the physiochemical milieu space for unanticipated enzyme behavior and rewards the discovery of experimental conditions that yield surprises
Keywords :
biology computing; genetic algorithms; laboratory techniques; molecular biophysics; proteins; search problems; enzymatic response; enzyme; evolutionary experimentation; evolutionary search strategy; factor space; genotypes; milieu conditions; physiochemical milieu space; Application software; Biochemistry; Biological system modeling; Biological systems; Chemicals; Computer science; Explosives; Proteins; Resource management; Shape;
Conference_Titel :
Evolutionary Computation, 2002. CEC '02. Proceedings of the 2002 Congress on
Print_ISBN :
0-7803-7282-4
DOI :
10.1109/CEC.2002.1006203
