Design and fabrication of cell adhesion measuring device

Author

Salehipour, Saeed ; Abolfathi, Nabiollah ; Hashemi, Ataallah

Author_Institution

Dept. of Biomedicai Eng., Amirkabir Univ. of Technol., Tehran, Iran

fYear

2014

Firstpage

324

Lastpage

328

Abstract

Cell adhesion phenomena has an important role on different behavior of cell. Therefore qualitative and quantitative understanding of cell adhesion force is necessary. A low cost micro device has been developed that can demonstrate cell adhesion force against a specific mechanical stimuli. The device that we developed here allows the measuring cell adhesion. This device is made based on poly methyl methacrylate (PMMA). Finally, to test the system functions, we obtained viscoelastic parameters of cell by applying 10 micron displacement that had a good agreement with literature.

Keywords

adhesion; bioMEMS; biological techniques; cellular biophysics; mechanical variables measurement; microfabrication; polymers; cell adhesion force; cell adhesion measuring device design; cell adhesion measuring device fabrication; cell adhesion phenomena; poly methyl methacrylate; specific mechanical stimuli; viscoelastic cell parameters; Adhesives; Biomedical engineering; Biomedical measurement; Force; Force measurement; Mathematical model; Springs; PMMA; cell adhesion force; in vitro; mechanical stimuli; microdevice; viscoelastic parameters;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering (ICBME), 2014 21th Iranian Conference on

Print_ISBN

978-1-4799-7417-7

Type

conf

DOI

10.1109/ICBME.2014.7043943

Filename

7043943