Title :
Bio-MEMS towards single-molecular characterization
Author :
Fujita, Hiroyuki
Author_Institution :
Center for Int. Res. on Micronano Mechatoronics, Univ. of Tokyo, Tokyo, Japan
Abstract :
MEMS devices, which are capable of handling fluids and objects as small as molecules, enabled bio analysis in the ultimate level of a single molecule. This review includes three recent developments: (1) Micromachined tweezers with sharp tips successfully captured a bundle of DNA molecules and allowed realtime observation of DNA degradation dynamics. (2) A rotational bio molecular motor was encapsulated in a fL-chamber. Exact correlation was obtained between rotational speed and ATP production/consumption. (3) A bio motor system, microtubules and kinesin, was reconstructed on a chip. The chip can distinguish normal and abnormal tau-proteins related to Alzheimer´s disease.
Keywords :
DNA; bioMEMS; biological techniques; diseases; molecular biophysics; proteins; reviews; ATP production-consumption; Alzheimer´s disease; DNA degradation dynamics; DNA molecules; bioMEMS; bioanalysis; biomotor system; encapsulation; fL-chamber; kinesin; micromachined tweezers; microtubules; review; rotational biomolecular motor; single-molecular characterization; tau-proteins; DNA; Microfluidics; Micromechanical devices; Nanobioscience; Proteins; Radiation effects; Resonant frequency;
Conference_Titel :
Electron Devices Meeting (IEDM), 2014 IEEE International
DOI :
10.1109/IEDM.2014.7047145
