DocumentCode :
3565501
Title :
Improvement of Markov chain processes for mathematical optimization of cancer treatment
Author :
Sbeity, Hoda ; Younes, Rafic ; Jammal, Manar
Author_Institution :
Univ. de Versailles, Versailles, France
fYear :
2014
Firstpage :
71
Lastpage :
76
Abstract :
Biologists have uncovered some of the most basic mechanisms by which normal cells develop into cancerous tumors. These biological theories can be transformed into adequate mathematical models. For this reason, we attempt to study the evolution of cancer cells using the Markov Chain Processes. Based on Markov chain Processes, cancer chemotherapy will be applied on them to treat the disease. However, chemotherapy is a complex treatment mode that requires balancing the benefits of treating tumors using anti-cancer drugs with the adverse toxic side-effects caused by these drugs. Some methods of computational optimization, Genetic Algorithm (GA) in particular, have proven to be useful in helping to strike the right balance. The purpose of this paper is to put in place a strategy to solve an optimal problem to facilitate finding optimal chemotherapeutic treatments which cause the death of cancer and have fewer side effects based on a chemotherapy treatment defined by the oncologist.
Keywords :
Markov processes; cancer; cellular biophysics; drugs; genetic algorithms; patient treatment; tumours; Markov chain process improvement; anticancer drug; cancer cell evolution; cancer chemotherapy; cancer treatment mathematical optimization; cancerous tumor; computational optimization; genetic algorithm; mathematical model; optimal chemotherapeutic treatment; Cancer; Drugs; Markov processes; Mathematical model; Optimization; Sociology; Statistics;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Engineering and Sciences (IECBES), 2014 IEEE Conference on
Type :
conf
DOI :
10.1109/IECBES.2014.7047599
Filename :
7047599
Link To Document :
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