Robust image registration using adaptive expectation maximisation based PCA

Images having either the same or different modalities can be aligned using the systematic process of image registration. Inherent image characteristics including intensity non-uniformities in magnetic resonance images and large homogeneous non-vascular regions in retinal and other generic image types however, pose a significant challenge to their registration. This paper presents an adaptive expectation maximisation for principal component analysis with mutual information (aEMPCA-MI) similarity measure for image registration. It introduces a novel iterative process to adaptively select the most significant principal components using Kaiser rule and applies 4-pixel connectivity for feature extraction together with Wichard´s bin size selection in calculating the MI. Both quantitative and qualitative results on a diverse range of image datasets, conclusively demonstrate the superior image registration performance of aEMPCA-MI compared with existing Mi-based similarity measures.